The Power Threat Meaning Framework has the potential to take us beyond medicalisation and diagnostic assumptions. It puts forward alternative ways of thinking about a range of fundamental issues including: What kinds of theoretical frameworks and assumptions are appropriate for understanding emotional distress, unusual experiences and troubled and troubling behaviour? What research methods could be used and what counts as evidence? How could the results of research be interpreted? What is the relationship between personal distress and its wider social, material and cultural contexts? How can we centre people’s lived experiences and the meanings that shape them? What new conceptualisations arise from all these questions, and how can all the implications be translated into practice, both within and beyond services, at all levels from individual to social policy?